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Penn Researchers Use AI to Surface Unreported GLP-1 Side Effects in Reddit Posts AI, Research and Innovation / April 10, 2026 By using AI to analyze more than 400,000 Reddit posts, Penn researchers have identified patient-reported symptoms associated with GLP-1s, the popular weight-loss and diabetes drugs semaglutide and tirzepatide, that may not be fully captured in clinical trials or regulatory documents

The protocols in use come from extrapolation of animal data, pharmacokinetic studies, and clinical experience from practitioners who have incorporated the compound into their practice

(C) Liver index (liver weight/body weight ratio)