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The lack of a well-defined primary receptor for DSIP has hampered mechanistic research if such a receptor exists, it has not been convincingly identified and cloned, leading some researchers to propose that DSIP may work through non-receptor-mediated mechanisms or through promiscuous interactions with multiple receptor systems

doi: 10.1126/scitranslmed.ado2084

One limitation is its short serum half-life of approximately 2 hours

(2020) HCG Modulates CXCL10 Expression Through Histone Methylation in Human Decidua PubMed ID: 32238853 Evans J (2016) Hyperglycosylated hCG: A Unique Human Implantation and Invasion Factor Am J Reprod Immunol 75(3):33340