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Br J Pharmacol

Independent testing of research peptide products has found significant variability in actual peptide content, including products that contained substantially less active compound than labeled, and products that failed sterility testing

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This is not surprising taking into account the highly flexible nature of IDPs/IDRs, which are best described as a protein clouds, and the fact that the utilized ensemble low-resolution techniques measure signals representing an average of all the states present in the conformational ensemble, and thereby conceal information about individual structures and their specific features