.6 semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial Semaglutides Are Poised to Remake

Using Vehicle control is standard practice, since it controls for the potential effects of treatment administration itself

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And GLPs are not recommended in patient populations with: severe gastrointestinal diseases such as gastroparesis and inflammatory bowel disease

The authors suggested that the reduction in glucose AUC 0120 min observed during the meal tolerance test was due to an incretin effect, and GLP1 also appeared to enhance muscle glucose uptake