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The heterogeneity of ADHD presentations and the complexity of its underlying neurobiology make it difficult to extrapolate findings from other conditions

That is critical for guiding clinical medication management, optimizing treatment strategies, and improving long-term prognosis in T2DM patients

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Multiple mechanisms drive pathological ROS accumulation in diabetic cardiomyocytes, such as inhibition of mitochondrial oxidative phosphorylation elevating O 2 production, activation of NOX by angiotensin II (Ang II) and TNF-, and AGEs-RAGE binding-induced NF-B activation that triggers inflammation and further ROS generation