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The Mayo Clinic's guidance on GLP-1 medications also emphasizes gradual dose titration to improve tolerability

Ma A, Wang J, Yang L, An Y, Zhu H

For treatment of primary systemic carnitine deficiency, a genetic impairment of normal biosynthesis or utilization of levocarnitine from dietary sources, or for the treatment of secondary carnitine deficiency resulting from an inborn error of metabolism such as glutaric aciduria II, methyl malonic aciduria, propionic acidemia, and medium chain fatty acylCoA dehydrogenase deficiency

By February 2026, eight GLP-1 RAs have received FDA approval, primarily for glycemic control in T2D and chronic weight management in obesity, with expanding cardiovascular (CV) benefits demonstrated in large-scale trials