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The second step involves 3-hydroxy- N -trimethyllysine aldolase enzyme (HTMLA gene) along with vitamin B6 as a cofactor.[ref] Carnitine absorption and cellular transport: SLC22A5 Carnitine is transported into cells using the OCTN2 transporter or through passive transport
The general principle of escalation observed in the trial involved starting at a low dose and titrating upward at approximately four-weekly intervals, with the highest-dose arm targeting 12 mg once weekly
A rigorous LC-MS pharmacokinetic study in rats would provide a definitive reference
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