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Stress, environmental toxins, and a lack of sleep can also deplete your natural stores

doi: 10.1007/s00167-018-5234-6

The rate of dropout in studies of oral semaglutide has been significant, approximately 25% in recent trials, reflecting tolerability concerns, mainly due to nausea (source)

For PWS patients, GLP-1 therapy represents a novel pharmacological approach that addresses the root neurobiological cause of hyperphagia rather than simply restricting calorie intake