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First, referring to the Tie-COPD study and PANTHEON study 9,14 , we calculated the sample size using Poisson regression analysis to detect a difference of 0.23 per patient-year between the N -acetylcysteine group (0.27 per patient-year) and the placebo group (0.50 per patient-year) in the annual rate of exacerbations, with a two-sided significance level of 5% and a power of 90% based on an anticipated withdrawal rate of 35%

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Moreover, in France identified a link between bad nutrition and depression incidence, it was most likely due to reverse causation, with depression raising the likelihood of poor eating habits (246)

The root is the first sensing organ that is initially affected by As exposure [25]