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A simple, practical supplement is often more appealing than complicated alternatives

Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivity

It may be helpful to provide patients with an optional ondansetron prescription for GLP-1 induced nausea, along with typical supports like clonidine and clonazepam once withdrawal begins

However, it should not be used in patients with type 1 diabetes or for treatment of diabetic ketoacidosis, and should not be coadministered with other GLP-1 receptor agonists or semaglutide-containing products