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Subsequent studies on ezutromid revealed that the lack of sustained therapeutic efficacy could be ascribed to the naphthalene unit, which is susceptible to hepatic CYP-mediated oxidation 10 (Fig

In physiological conditions, NLRP-6 activation leads to secretion of IL-18 and IL-1 via caspase-1

Summary The use of GLP-2 analogs is effective in the management of SBS-IF and may show promise in the treatment of other severe gastrointestinal disorders associated with loss of effective intestinal resorptive surface area