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This creates an energy deficit that pulls from both fat and lean stores

The inability to account for dosing intensity or adherence limits our capacity to establish doseresponse relationships, assess whether the magnitude of benefit varies with treatment exposure, or determine whether non-adherence attenuated the observed effects

GLP-1 microdosing is the medical practice of administering very small doses of a drug, often to provide dose-specific benefits that might be different than the regular dose, while minimizing side effects

The study confirmed that semaglutides pro-osteogenic effects are mediated through this pathway by using a Wnt inhibitor (DKK1) and activator (LiCl)