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Male gender, hypertension, hyperlipidemia, diabetes mellitus, coronary heart disease, sleep apnea, a history of cardiovascular medications, and being heterozygous for Factor V Leiden risk factors were associated with NAION

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As MC4R deficiency presents with severe obesity from childhood, trials of tirzepatide (NCT06439277 and NCT06075667) and other obesity medications in children and adolescents with obesity, including those with MC4R deficiency, are needed to provide the evidence base for earlier, and potentially chronic, treatment in genetically driven obesity

In comparison, the time course of the calculated absolute counts of the latter ( Supplementary Table 3 ) was similar to that of the absolute granulocyte counts