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Reduced muscle mass can contribute to slower weight loss and lower energy levels

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this activation can increase the expression of proinflammatory cytokines such as IL-1, IL-6, TNF- and COX-2 to regulate the inflammatory response and unbalance the MMPs/tissue inhibitors of metalloproteinases (TIMPs) ratio by activating MMPs and reducing TIMPs expression, thereby decompressing the ECM (6,31,41)

In conclusion, MQC is an integrated network that monitors mitochondrial quality and works in concert to maintain mitochondrial homeostasis by coordinating various processes, including mitochondrial biogenesis, mitochondrial autophagic degradation, and the balance of mitochondrial dynamics (fission, fusion) (Zhou et al., 2023)