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The resulting membrane depolarization due to KATP inhibition, together with direct activation of VDC channels, facilitates calcium influx and promotes insulin granule exocytosis

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Muscle Preservation During GLP-1 Therapy: Why Creatine May Help Rapid weight loss on GLP-1 medications can result in 20-30% lean muscle loss alongside fat loss, reducing metabolic rate and increasing rebound weight-gain risk

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Khera AV, et al

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