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If somebody has blood glucose that is really poorly controlled, and then they get really well controlled rapidly [with GLP-1s], that can actually cause flares of retinopathy, said Ferris

Further large-scale, multicenter clinical trials are needed to elucidate their efficacy and safety

Perez added that you should also discuss other practical questions with your doctor before taking a weight loss medication, such as whether you are a good candidate for bariatric surgery

Additionally, the majority of studies did not report adverse events stratified by age within adults, thus preventing subgroup analyses comparing adult and elderly subjects