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This disorder was not described until 1983 and the estimated incidence of MCAD is approximately 1:12,000 live births
This is achieved because of the nature of FreSHtracer, which can pass through the cell membrane and react with the thiol of GSH in the cell with high efficiency, unlike other fluorescent dyes that have several shortcomings such as irreversibility, slow kinetics [38], and low fluorescent quantum yields [39]
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This was achieved by demethylating the promoters of 14-3-3, CHK2 and DAPK-1 genes, promoting the expression of these genes, and then activating the G2/M checkpoint response in osteosarcoma cells, to improve the radiotherapy effect of osteosarcoma 10 (Figure 1 and Table 1)
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