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Eur Heart J 43(45):46794693 Chintanaphol M, Orgil BO, Alberson NR, Towbin JA, Purevjav E (2022) Restrictive cardiomyopathy: from genetics and clinical overview to animal modeling

Generic manufacturers who attempted to replicate the abuse-deterrent properties through alternative polymers were unable to secure FDAs abuse-deterrent labeling, which meant their label explicitly disclaimed the deterrent properties that Purdue claimed a commercial disadvantage that depressed their market share even after launch

The manufacturers of tirzepatide are also required to report safety updates to health agencies regularly

Mechanism: It is the first triple hormone receptor agonist to reach Phase 3 clinical trials