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470,478,482,483,484 GLP-1RAs in the digestive system Treatment with GLP-1RAs can alleviate insulin signaling by reducing the phosphorylation of Akt protein (Decreased Akt-P) and activating Protein Kinase C- (PKC-)

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Transdermal delivery bypasses the digestive system, ensuring faster absorption and higher bioavailability of the active ingredients, leading to more effective and consistent results

it also neutralizes free radicals