Grima G, Benz B, Parpura V, Cunod M, Do KQ
LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al
Home remedies with genuine evidence behind them for reducing alcohol consumption include kudzu root extract (clinically shown to reduce drinks per session), L-glutamine (reduces craving intensity by stabilising blood sugar and supporting GABA), regular exercise (restores dopamine balance disrupted by alcohol), and dietary changes that eliminate blood sugar volatility
These should include: Weight and BMI monitoring to assess treatment effectiveness Blood pressure checks , as weight loss can affect blood pressure Review of side effects and overall treatment tolerance Periodic blood tests as clinically indicated, which may include HbA1c (for diabetes monitoring), liver function tests, and renal function When to seek urgent medical advice: Symptoms of severe hypoglycaemia (confusion, loss of consciousness, seizures) Severe, persistent abdominal pain, which could indicate pancreatitis (a rare but serious side effect of GLP-1 receptor agonists) [2] [7] Sudden right upper abdominal pain, fever, or jaundice, which could indicate gallbladder disease (risk increased with rapid weight loss) Persistent vomiting leading to dehydration Signs of allergic reaction (rash, swelling, difficulty breathing) Symptoms of thyroid problems (lump in the neck, hoarseness, difficulty swallowing) Quality considerations for berberine supplements are important, as these products are not subject to the same regulatory oversight as medicines
