Described as a clinical-histopathological definition in 1980, nonalcoholic steatohepatitis (NASH) [1], now renamed metabolic dysfunction-associated steatohepatitis (MASH) [2], has remained a neglected area for drug development for decades
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While GLP-1 agonists like retatrutide generally protect against fatty liver disease, combining them with regular alcohol consumption creates potential hepatotoxic concerns due to prolonged alcohol exposure and altered acetaldehyde metabolism
Key questions remain, including how the drugs should be used in people who dont have excess weight
