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At the same time, obesity is rising rapidly across age groups.

The study results revealed that the direct tumoral administration of the iontophoretic entity causes increased efficacy or therapeutic index due to bypassed systemic exposure of the immunotherapeutic agent as well as drastically changes the toxicity profile of the immunotherapeutic agent [207]

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Forget P, Wittebole X, Laterre PF: Therapeutic dose of acetaminophen may induce fulminant hepatitis in the presence of risk factors: a report of two cases