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Description

No single direct pharmacological mechanism has been definitively established

Efficacy and safety of once-weekly tirzepatide for weight management compared to placebo: an updated systematic review and meta-analysis including the latest SURMOUNT-2 trial

Titration Design In the Phase 2 trial published in The New England Journal of Medicine , participants started on a low introductory dose (as little as 24 mg weekly) and were titrated upward over the course of several weeks before reaching target doses of 812 mg