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By 2030, more than half of American adults are expected to be classified as obese, with a substantial increase in severe obesity.[56] If unaddressed, this trend will further erode Americas economic potential, placing unprecedented strain on public programs, employer budgets, and national productivity

doi: 10.3389/fphar.2026.1752204 Received 22 November 2025 Revised 15 April 2026 Accepted 21 April 2026 Published 15 May 2026 Volume 17 - 2026 Edited by Sathish Kumar Natarajan, University of Nebraska-Lincoln, United States Reviewed by Fabio Vivarelli, University of Bologna, Italy Vijay Radhakrishnan, University of Missouri, United States Updates Copyright 2026 Mahalingam, Kharbanda, Casey and Rasineni

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Symptoms such as facial swelling, lip or tongue swelling, breathing difficulties, or a rapidly spreading rash require urgent medical attention