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It was reported that the increased fat/lean mass ratio persisted even if normal weight was achieved in PWS patients [26]

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Neuronal hyperexcitability can be a common link between CVS and other central nervous system (CNS) disorders.3840 Hyperexcitability can be a consequence of genetic variants in the structure and function of the ion channel and/or neurotransmitter receptors or can be the result of an aberrant development of neuronal circuits