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It should not be expected to reverse severe osteoarthritis, regrow advanced cartilage loss, correct major joint deformity, heal a complete tendon rupture without appropriate orthopedic management, or replace surgery when surgery is clearly indicated

Each has its own trade-offs

Low IGFBP2 is linked to metabolic syndrome and insulin resistance, whereas higher IGFBP2 is associated with lower fasting glucose and insulin but increased mortality in older adults, independent of CRP and IL-6 [154, 155]

The difference is professional oversight: board-certified nurses monitoring your response, adjusting doses, and ensuring safety every step of the way