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rhamnosus not only induce an anti-inflammatory phenotype in M2 macrophages but also make M1 macrophages convert to a less inflammatory phenotype by suppressing the immune activation markers like CD14, CD80, and HLA-DR also decrease pro-inflammatory cytokines like IL-12, IL-1, and TNF- and increase anti-inflammatory cytokines like IL-10 and TGF- in SLE patient macrophages ( Figure 2 ) (101)

Second, severe or persistent symptoms may point to a more serious problem, especially if they cause dehydration or worsening abdominal pain

The following day, the cells were treated with 10 M CMFDA for 1 h, then fixed in 4% paraformaldehyde/4% sucrose in PBS (15 min at RT)

Susan Brown, PhD, a New York State Certified Nutritionist