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Colonic butyrate producers shape the gut microbial community by secreting various anti-microbial substances, such as cathelicidins, reuterin, and -defensin-1, and maintain gut homeostasis by releasing anti-inflammatory molecules, such as IgA, vitamin B, and microbial anti-inflammatory molecules

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Within the brain ethanol-derived acetate has been found to directly bind to neuronal chromatin where it is converted to acetyl-CoA via chromatin-bound acetyl-CoA synthetase 2 (ACSS2)

If a satisfactory clinical response is achieved, treatment should be continued for at least 12 months