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Commenters stated that such methodologies or reimbursement structures are often protected under intellectual property agreements or confidentiality clauses in hospital contracts, and requiring hospitals to encode such logic in the MRF could expose them to contractual breaches or legal liability

There are three main ways: Methylmalonic acid (MMA) MMA is one of the most useful markers for detecting B12 deficiency, because B12 helps convert methylmalonyl-CoAone of the forms of MMAinto succinyl-CoA