The analysis revealed that weight loss accounted for only 13% and 21% of the improvement in HOMA2-IR with tirzepatide (10 mg and 15 mg, respectively), indicating that weight loss was only partially responsible for the observed improvements in insulin resistance
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The trial evaluated once-weekly subcutaneous semaglutide 2.4 mg versus placebo in reducing the risk of MACE (a composite endpoint comprising CV death, nonfatal MI or nonfatal stroke) in individuals with established ASCVD and overweight or obesity but without diabetes
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