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Classical symptoms include: Weight loss Palpitations Anxiety Eye bulging Tremors Irritability Infrequent menstrual periods Fatigue Heat intolerance Increased appetite Hair loss Enlarged thyroid gland Sweating Frequent bowel movements Infertility Soft nails Warm, moist palms Finger tremors Insomnia Muscle weakness Nervousness Symptoms of Hypothyroidism Some of the more common symptoms of hypothyroidism, or deficiency of thyroid hormone, include: Slower metabolism leading to weight gain Forgetfulness Feeling cold or cold intolerance Depression Fatigue Dry skin Constipation Loss of ambition Dry, coarse hair Muscle cramps Stiffness Joint pain A loss of the outer third eyebrow Heavy menstrual periods Infertility Muscle aches Puffy face Slow heartbeat Brittle nails Arthritis These symptoms may be present in any combination in people with thyroid disorders, but the degree to which they impact an individual can vary greatly as well

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The aim is to relieve symptoms without affecting how well the treatment can be handled

Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors