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As the vagus activity is increased by stimuli of gastric distension, cholecystokinin (released from the digestion of fat and proteins), and nutrients that induce satiety, it was expected that vagotomy would inhibit the signals reaching the CNS and would result in excess food intake [31]

As anticipated, the low-calorie diet led to an increase in CTX (+ 27%) and PINP (+ 7%), indicating increased bone turnover favoring bone resorption [74] ( Fig