It is contraindicated for individuals with hypercalcemia, hypercalciuria, or severe renal impairment
Do not take Rybelsus if you: Are allergic to semaglutide or any other ingredients in the medication Are pregnant or breastfeeding Have medullary thyroid cancer (MTC) Have multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Before taking Rybelsus, inform your doctor if you: Are pregnant or breastfeeding Ever had pancreatitis Have medullary thyroid cancer (MTC) or multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Have type 1 diabetes, develop ketoacidosis (increased ketones in blood or urine) Have a high heart rate Have end-stage renal disease or liver disease Have diabetic retinopathy Have digestive problems like vomiting, diarrhea or dehydration Drug interactions Tell your doctor, nurse, or pharmacist about all the medicines you take, including drugs prescribed by other doctors, vitamins, minerals, natural supplements, or alternative medicines
However, developers of GLP-2 therapies for chronic IBD will need to address prescriber concerns regarding long-term trophic effects and the necessity for mucosal dysplasia surveillance
GLP-1 medications can also have positive effects, such as increased confidence and energy
