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They mimic naturally occurring gastrointestinal hormones such as glucagon-like peptide (GLP-1) and gastric inhibitory peptide (GIP) that suppress appetite after eating and stimulate the release of insulin from the pancreas

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Fortunately, cyclosporine lacks a diverse array of functionalized amino acids, allowing the difficult couplings at the N -methylated terminus to be accomplished via the formation of a reactive acid chloride

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