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Similar content being viewed by others Introduction PENs constitute the most important group of antibiotics and remain the first-line therapy for many infectious diseases due to its high antibacterial activity and low medical burden 1,2,3

In vivo growth models: IGF-1 LR3 is more commonly selected for extended in vivo research due to its superior half-life and IGFBP resistance

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In this study we also used GWAS summary data from the GTExPortal ( and the IEU OpenGWAS project ( and the authors thank all of the investigators who provided these data to support this study