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In the superficial spinal dorsal horn and over short time periods NO is likely to be produced essentially by NOS localized in dorsal root ganglia and primary afferent terminals

Combined SGLT2i and GLP-1RA therapy was also associated with 57% lower odds of HF when compared with other combination regimens (OR, 0.43

Although preclinical studies have illustrated that pure nanotherapeutics possess some therapeutic functions, challenges still remain in their low accumulation at the targeted areas and easy leakage, which may cause therapeutic inefficiency to hinder subsequent clinical translation 23,24,25

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