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Clinical trial data for retatrutide, including Phase 2 results published in the New England Journal of Medicine (Jastreboff et al., 2023), identified gastrointestinal adverse events as the most common side effects reported by participants

On the contrary, other observational analyses of AF populations did not reveal significantly elevated risk of bleeding in patients with comorbid DM [16, 20, 21, 68]

Rather than taking a large weekly dose that might cause nausea, some providers suggest splitting the semaglutide dosage in units to be taken twice weekly