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B12 also plays a role in the production of melatonin, a hormone that helps regulate our circadian rhythms

c-MYC, whose expression level was significantly higher in the KO group, could also be activated by Shh

We starved cells of cystine and supplemented the media without or with cystine for 3 h

Bax, a pro-apoptotic Bcl-2 family protein, resides in the cytoplasm and translocates to the mitochondria in response to apoptotic stimuli, where it facilitates the release of Cyt C (Shalini et al., 2015)