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When evaluated after exposure to LASSS at a 1:8000 molar ratio to HGF and subsequent ultra-filtration to wash-out un-reacted free LASSS, c-met binding affinity increased more than two-fold over the original non-nitrated HGF

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However, this study suggests something even broader

Johri AM, Heyland DK, Hetu MF, Crawford B, Spence JD