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Additionally, paeoniflorin was reported to reduce the expression of the L-tryptophan-catabolizing enzyme tryptophan-2,3-dioxygenase in the liver of stress-induced depressive mice, thereby increasing the 5-hydroxytryptamine/tryptophan ratio and decreasing the kynurenine/tryptophan ratio (Liang et al., 2023)

Neurodevelopmental disorders and cancer To that point, the researchers also identified glutathione-linked molecular mechanisms that may contribute to very different diseases