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These contrasting findings might be explained by substantial differences in study design, sample, and reward phase

Kumbhar et al

For most people that's straightforward but there are a few things that make the experience noticeably better

Superiority of Oxaliplatin and Fluorouracil-Leucovorin Compared with Either Therapy Alone in Patients with Progressive Colorectal Cancer after Irinotecan and Fluorouracil-Leucovorin: Interim Results of a Phase III Trial