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Moving forward, the results of the phase 3 SURPASS clinical trial program demonstrated that tirzepatide was as effective and safe as other anti-diabetic agents, such as semaglutide and dulaglutide (SURPASS-2) (SURPASS J-mono), long-acting insulin analogs (degludec and glargine) (SURPASS-3,4), and placebo (SURPASS-1) (SURPASS-5), in managing T2DM diabetes [65,66,67,68,69]

10.3389/fphar.2021.629798 239 YouL.FangZ.ShenG.WangQ.HeY.YeS.et al (2019)

If you plan to resume after a break, the plotter shows that you essentially restart the accumulation process from zero (or near zero, depending on break length)

doi: 10.1507/endocrj.EJ20-0062 48 PirolaIGandossiEAgostiBDelbarbaACappelliC