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After a growing number of hearing damage lawsuits had been filed against the manufacturer, Horizon Therapeutics ultimately revised the cautionary labeling of Tepezza in July 2023, acknowledging that Tepezza side effects may cause severe hearing impairment, which can be permanent in some cases

Clinical trials demonstrating measurable improvements in collagen density and skin elasticity have generally used protocols spanning 412 weeks of consistent use

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Domperidone carries a risk of QT interval prolongation and serious cardiac arrhythmias , and is subject to prescribing restrictions