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When scientists looked at standard, naturally occurring IGF-1, they noticed a massive roadblock: as soon as it enters the bloodstream, the body binds it up using IGF Binding Proteins (specifically IGFBP-3)

Type 1 diabetes mellitus (T1DM) is characterized by an absolute deficit of pancreatic -cells caused by autoimmune-mediated destruction, whereas insulin resistance and abnormal insulin secretion are central to the development of type 2 diabetes mellitus (T2DM)

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