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Notably, controlled fluid flow introduces sustained perfusion and physiologically relevant shear forces, both of which modulate cellular behaviour and allow for a more accurate assessment of nanoparticle transport, distribution and cellular uptake than static in vitro models [175, 176]

When analyzing samples exposed to PURE G4 -LA 12 -anti- GLS1 -siRNA from both cell lines, there was a tendency for increased extracellular levels of formate and GSH comparing to samples exposed to PURE G4 -LA 12 (Fig

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