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608 Morroniside activates the Nrf2/ARE pathway, upregulates GPX4, SLC7A11, FTH1, and FPN expression, increases GSH content, and decreases MDA and iron levels

This approach also means any initial nausea happens when you're resting, making it less noticeable than if it occurred during your workday

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On the other hand, overexpression of Nrf2 (transcriptional regulator of seleno-GPxs) contributed to the increase in the radioresistance and stemness in glioma stem cells (GSCs) by upregulating GPx1 and decreasing the cellular ROS level