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33 Published online: July 25, 2022

K.ShinW

95% CI, 0.78-0.99) and dementia (HR = 0.92

The aggregate evidence from randomized controlled trials and meta-analyses indicates potential benefit for fasting glucose, HbA1c, and indices of insulin resistance, though findings are not uniform across studies ( Residual heterogeneity across trials is attributable to differences in baseline glycemic status, concomitant pharmacotherapy, intervention duration, administered dose, and the pharmacokinetic profile of the specific formulation employed