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The final structures were deposited in the Protein Data Bank under accession codes 9HMC (PDE 5e ) and 9HMD (PDE 6a ), with detailed data collection and refinement statistics provided in Supplementary InformationSupplementary Table 5

Industry surveys and case studies show growing engagement: at FDAs September 2023 workshop, about one-third of attendees reported actively using AI for process monitoring or quality analysis, and many planned to submit regulatory applications involving AI-composed products or processes ( [19] )

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