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These interventions not only help individuals achieve weight loss but also improve related health conditions, such as diabetes, hypertension, and sleep apnea , ultimately enhancing quality of life and longevity, Dr

The development of DR is complex, and it involves increased production of free radicals, the stimulation of AMP-activated protein kinase/mammalian target of rapamycin signaling pathways, the activation of the renin-angiotensin system, engagement of TGF-/Smad signaling, the kinin system involving kinin-releasing enzymes, the accumulation of AGEs and various inflammatory agents such as VEGF (136-138)

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