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Highlights Ubx homodimerization enables decoupling of DNA- and RNA-dependent splicing regulation The homeodomain K58 amino acid is critical for Ubx-RNA binding ability Ubx-RNA binding ability is essential for splicing regulation Dual DNA/RNA binding activities shape Ubx homeotic functions INTRODUCTION Transcription factors (TFs) play a critical role in coordinating the development of multicellular organisms by regulating precise gene expression programs 1,2

The lower bacterial mucinolytic activity is supposed to contribute to the slower mucus turnover and to the leaky gut, leading to intestinal inflammation

Cost-effectiveness of once daily GLP-1 receptor agonist lixisenatide compared to bolus insulin both in combination with basal insulin for the treatment of patients with type 2 diabetes in Norway